I generally vape mine until it is very low, pour out the last few drops, and refill. I have 12 tanks in rotation and I clean and put in new coils in all of them once every couple months (approx every 5-6 refills) and do them all at the same time because it is just easier for me to do it that way.
I do notice my KPT 2s will get dark and funky a lot quicker than my Davide minis do even though I only use the KPT 2s on the weekend and use the Davide minis all week.