I do, about 3,000 chemical differences. Smoking, taste and habit. Breathing changes, blood pressure, cholesterol.. I'm aware going from My 6-12 mg of nicotine to surprise 18 put my head in a spin literally, so I worry. My last puff off analog after a month of no smoking I could feel vasoconstriction. I was concerned about nic as I said, but choice to vape is yours an yours alone.