In an unregulated MOD, Ohm's Law is the only way it works, lol... Coil resistance and battery voltage determine the Wattage (output) and Amp-draw. A 0.2 Ohm coil fired at 4.1V (fully charged single battery or two batteries in parallel-mode) will draw 20.5A (minimum) and output 84W. This is safe as long as your battery (or batteries) are good batteries and rated 20A, like the Samsung 25R, Sony VTC4, or LG HE2/HG2.
Now, in series, two batteries are capable of double Voltage (8.2V), so at that power level, the Amp draw will be 41A and 336W of output at the coil Your batteries won't handle that load, and @ 336W, neither will your lungs In a Mech MOD, there's now way to "dial it down" either... It's either full on, or full off, and the Wattage is solely determined by the coil's resistance and the Voltage provided by the battery/batteries!
A regulated box MOD will make your vape more consistent and controllable, than dealing with the constant Voltage drop of a draining battery in a Mech MOD. I don't own either of the two regulated MODs you mentioned, but I've heard many positive things about the Wismec rx200. @jasonculp will be along shortly to give you more info on larger box-mods like the rx200.
Let me add in this as well... Wattage ratings stamped on the factory coils mean very little... I frequently use a coil stamped 30-60W (for example) at a "comfortable" vaping range around 16-18W... to me, cranking it up to even 20W gives me a burnt taste, so you MUST also consider what your juice can handle... As I like to say... just because your car's speedometer registers 150mph, doesn't mean you HAVE to pull out of your driveway at 150mph!!