Drawbacks? Nope, no drawbacks at all.
Well, if you don't count that obsession thing. The one where you just HAVE to have it in your hand at all times, where you just HAVE to see what's going on in VT all the time, where you just HAVE to check out all the new PVs, where you just HAVE to have some of those new PVs, where you just HAVE to have lots and lots of backups, where you just HAVE to try ALL of the flavors out there...you know...that obsession.
Oh wait!! I know one!! A carton of analogs, an ashtray, and a lighter take up a LOT less space than the hoard stash of vaping supplies. I never once, in 34 years of smoking, ever considered having a special room set aside for my smoking supplies...but for vaping supplies, well...